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Review
. 2012:353:111-21.
doi: 10.1007/82_2011_149.

Nuclear Editing of mRNA 3'-UTRs

Ling-Ling Chen  1 , Gordon G Carmichael
Affiliations
Review

Nuclear Editing of mRNA 3'-UTRs

Ling-Ling Chen et al. Curr Top Microbiol Immunol. 2012.

Abstract

Hundreds of human genes express mRNAs that contain inverted repeat sequences within their 3'-UTRs. When expressed, these sequences can be promiscuously edited by ADAR enzymes, leading to the retention of mRNAs in nuclear paraspeckles. Here we discuss how this retention system can be used to regulate gene expression.

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