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Review
. 2011 Nov;25(11):1674-86.
doi: 10.1038/leu.2011.167. Epub 2011 Jul 5.

Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!

C V Borlongan  1
Affiliations
Review

Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!

C V Borlongan. Leukemia. 2011 Nov.

Abstract

Mobilizing bone cells to the head, astutely referred to as 'bonehead' therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke.

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Conflict of interest statement

Conflict of interest

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Bone marrow-derived stem cells. Schematic diagram shows subsets of bone marrow-derived stem cells, including HSCs, MSCs, EPCs and VSELs, that have been examined in the laboratory and are rapidly being translated into clinical applications as efficacious stem cell sources for transplantation therapy in stroke.
See this image and copyright information in PMC

References

    1. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood. 2003;102:3483–3493. - PubMed
    1. Munoz-Elias G, Woodbury D, Black IB. Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor function. Stem Cells. 2003;21:437–448. - PubMed
    1. Hess DC, Borlongan CV. Cell-based therapy in ischemic stroke. Expert Rev Neurother. 2008;8:1193–1201. - PMC - PubMed
    1. Hara K, Yasuhara T, Maki M, Matsukawa N, Masuda T, Yu SJ, et al. Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. Prog Neurobiol. 2008;85:318–334. - PubMed
    1. Hess DC, Borlongan CV. Stem cells and neurological diseases. Cell Prolif. 2008;1:94–114. - PMC - PubMed

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