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Comparative Study
. 1990 Nov;87(21):8331-5.
doi: 10.1073/pnas.87.21.8331.

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor

T Kohno  1 , M T Brewer, S L Baker, P E Schwartz, M W King, K K Hale, C H Squires, R C Thompson, J L Vannice
Affiliations
Comparative Study

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor

T Kohno et al. Proc Natl Acad Sci U S A. 1990 Nov.

Abstract

An inhibitor of tumor necrosis factor (TNF) has been isolated from the human histiocytic lymphoma cell line U-937 that is capable of inhibiting both TNF-alpha and TNF-beta. Protein sequencing has verified that it is distinct from a previously described TNF inhibitor that is a soluble fragment of a TNF receptor molecule (TNFrI). The cDNA sequence of this second TNF inhibitor clone suggests that it is also a soluble fragment of a TNF receptor. Expression of this cDNA sequence in COS-7 cells verified that it encodes a receptor for TNF-alpha (TNFrII) that can give rise to a soluble inhibitor of TNF-alpha, presumably through proteolytic cleavage. The extracellular domain of TNFrII has significant homology with that of TNFrI and these two receptors share a striking conservation of cysteine residue alignment with the extracellular domain of the nerve growth factor receptor. These three receptor molecules are therefore members of a family of polypeptide hormone receptors.

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References

    1. J Mol Biol. 1970 Mar;48(3):443-53 - PubMed
    1. Science. 1990 May 25;248(4958):1019-23 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. Anal Biochem. 1976 May 7;72:248-54 - PubMed
    1. Science. 1977 Apr 8;196(4286):180-2 - PubMed

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