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. 1990 Oct;124(1):107-9.

Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278

E A Holwitt  1 , E Koda, C E Swenberg
Affiliations
  • PMID: 2173013

Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278

E A Holwitt et al. Radiat Res. 1990 Oct.

Abstract

The radioprotector WR-33278, the disulfide of WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane), is shown to stimulate eukaryotic topoisomerase I unwinding of negatively supercoiled DNA. This observation suggests the possibility that some protection may be conferred to DNA either by a decrease in its supercoiled state or by altering directly other enzymatic processes. This is the first report of a radioprotective compound stimulating an enzyme involved in DNA structure and synthesis.

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