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Case Reports
. 2011 Aug;32(6):969-72.
doi: 10.1097/MAO.0b013e3182255893.

Cisplatin ototoxicity affecting cochlear implant benefit

Michael S Harris  1 , Jaimie L Gilbert, Kelly A Lormore, Swapna A Musunuru, Michael H Fritsch
Affiliations
Case Reports

Cisplatin ototoxicity affecting cochlear implant benefit

Michael S Harris et al. Otol Neurotol. 2011 Aug.

Abstract

Objective: Report a case of loss of cochlear implant benefit after cisplatin therapy to treat osteosarcoma. Examine the implications for the loci of cisplatin-associated cochleotoxicity.

Study design: Retrospective case review.

Setting: Tertiary referral center.

Patients: Single case study.

Intervention(s): None.

Main outcome measure(s): Cochlear implant programming levels.

Results: Increase in cochlear implant programming T- and C-levels after cisplatin therapy.

Conclusion: Cisplatin therapy likely affects spiral ganglion cells. It seems that auditory cells other than outer hair cells in the organ of Corti are affected by cisplatin because the hearing sensitivity of this patient with nonfunctioning outer hair cells declined after receiving chemotherapy. Implications of these findings are discussed.

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Figures

FIG. 1
FIG. 1
Pre-CI unaided (solid line), pre-CI aided (dashed line), and 1-year post-CI hearing levels (dB) for tested frequencies (Hz). Pre-CI unaided, pre-CI-aided, and post-CI thresholds were obtained using warble tone stimuli. The downward pointing arrow indicates no response to the limit of the audiometer at 4000 Hz for the pre-CI aided condition. Pre-CI aided thresholds were obtained using binaural acoustic amplification.
See this image and copyright information in PMC

References

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