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Case Reports
. 2010 Jul;14(2):77-9.
doi: 10.4103/0973-029X.72507.

Keratoameloblastoma of the mandible

Bf Adeyemi  1 , Ao Adisa, Ao Fasola, Ee Akang
Affiliations
Case Reports

Keratoameloblastoma of the mandible

Bf Adeyemi et al. J Oral Maxillofac Pathol. 2010 Jul.

Abstract

Keratoameloblastoma is a very rare ameloblastoma variant defined by extensive squamous metaplasia and keratinization. There are 13 previously reported cases in the literature, with a male predilection of 3:1. A 38-year-old male presented with a painless mandibular swelling which had been progressively increasing in size for 18 months. The incisional biopsy was misdiagnosed as basaloid squamous carcinoma. Owing to financial constraints, the patient had mandibular resection a decade after first noticing the growth, during which the clinical course was essentially benign, thus casting doubt on the initial diagnosis. The final histological diagnosis for both the incisional and resection biopsy specimens was keratoameloblastoma.

Keywords: Keratoameloblastoma; ameloblastoma; keratinization; mandible; misdiagnosis; prognosis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Photomicrograph displaying features of plexiform ameloblastoma with focal areas of squamous metaplasia (thick arrow) and myxoid stroma (thin arrow) (H and E, ×100)
Figure 2
Figure 2
Photomicrograph displaying extensive areas of squamous differentiation within the neoplasm (black arrows) (H and E, ×50)
Figure 3
Figure 3
Photomicrograph displaying areas of lamellate parakeratin deposition within the connective tissue stroma, reminiscent of Pacinian corpuscles (thin arrow) and a plexiform pattern (thick arrow) (H and E, ×100)
Figure 4
Figure 4
Photomicrograph from original biopsy displaying features consistent with ameloblastoma with plexiform islands of odontogenic epithelium (thick arrow) and focal squamous metaplasia (thin arrow) (H and E, ×100)
See this image and copyright information in PMC

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