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. 1990 Nov 9;250(4982):830-2.
doi: 10.1126/science.2173142.

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

D H Hsu  1 , R de Waal Malefyt, D F Fiorentino, M N Dang, P Vieira, J de Vries, H Spits, T R Mosmann, K W Moore
Affiliations

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

D H Hsu et al. Science. .

Abstract

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.

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