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. 2011 Jun 15;3(6):79-98.
doi: 10.4251/wjgo.v3.i6.79.

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Alexandra Mj Langers  1 , Hein W Verspaget, Daniel W Hommes, Cornelis Fm Sier
Affiliations

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Alexandra Mj Langers et al. World J Gastrointest Oncol. .

Abstract

Matrix metalloproteinases (MMPs) are implicated in cancer development and progression and are associated with prognosis. Single-nucleotide polymorphisms (SNPs) of MMPs, most frequently located in the promoter region of the genes, have been shown to influence cancer susceptibility and/or progression. SNPs of MMP-1, -2, -3, -7, -8, -9, -12, -13 and -21 and of the tissue inhibitor of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors. The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper.

Keywords: Digestive tract; Matrix metalloproteinase; Promoter region; Single nucleotide polymorphism; Tissue inhibitor of metalloproteinase; cancer.

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Figures

Figure 1
Figure 1
Schematic overview of the various types of matrix metalloproteinase-producing cells that are involved in the different processes during the various stages of cancer. MMP: Matrix metalloproteinase; TIMP: Tissue inhibitor of metalloproteinase.
Figure 2
Figure 2
Forest plot of gastrointestinal cancer risk associated with the MMP-2 -1306 C/T polymorphism. Results are expressed as Odds ratios ± 95% confidence interval (CI) for CC vs CT+TT. The size of the diamonds indicates the size of the study cohort.
See this image and copyright information in PMC

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