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. 2011 Aug 1;21(15):4485-9.
doi: 10.1016/j.bmcl.2011.06.010. Epub 2011 Jun 16.

Limonoids from seeds of Thai Xylocarpus moluccensis

Warin Ravangpai  1 , Damrong Sommit, Thapong Teerawatananond, Nuntawan Sinpranee, Tanapat Palaga, Somchai Pengpreecha, Nongnuj Muangsin, Khanitha Pudhom
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Limonoids from seeds of Thai Xylocarpus moluccensis

Warin Ravangpai et al. Bioorg Med Chem Lett. .

Abstract

A new andirobin, thaimoluccensin A (1), and two new phragmalin-type limonoids, thaimoluccensins B (2) and C (3), were isolated from seeds of a Thai mangrove plant, Xylocarpus moluccensis, together with eight known compounds. The structures of these compounds were elucidated on the basis of spectroscopic data. Only 7-deacetylgedunin (7), a gedunin-type limonoid, exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC(50) value less than 10 μM, suggesting that the compound has anti-inflammatory activity.

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