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. 2011 Jul;85(1):3-5.
doi: 10.4269/ajtmh.2011.11-0160.

Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages

Kevin C Kobylinski  1 , Massamba Sylla, Phillip L Chapman, Moussa D Sarr, Brian D Foy
Affiliations

Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages

Kevin C Kobylinski et al. Am J Trop Med Hyg. 2011 Jul.

Abstract

Ivermectin mass drug administration (MDA) to humans is used to control onchocerciasis and lymphatic filariasis. Recent field studies have shown an added killing effect of ivermectin MDA against malaria vectors. We report that ivermectin MDA reduced the proportion of Plasmodium falciparum infectious Anopheles gambiae sensu stricto (s.s.) in treated villages in southeastern Senegal. Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. It could be a powerful and synergistic new tool to reduce malaria transmission in regions with epidemic or seasonal malaria transmission, and the prevalence and intensity of neglected tropical diseases.

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Figures

Figure 1.
Figure 1.
Field site map. Topographical map of the five villages where the experiment was conducted in 2008 and 2009.
Figure 2.
Figure 2.
The proportion of Plasmodium falciparum infectious Anopheles gambiae s.s. before and after ivermectin MDAs. The mean percent of P. falciparum sporozoite-infectious An. gambiae s.s. were estimated from three replicate collections of mosquitoes in treated and pair-matched untreated, control villages in southeastern Senegal. Filled (•) and open (○) circles represent the means of ivermectin treated and untreated control villages, respectively. Error bars represent 95% confidence intervals.
See this image and copyright information in PMC

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