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Randomized Controlled Trial
. 2011 Nov;53(5):497-501.
doi: 10.1097/MPG.0b013e31822b7ab0.

Treatment of acute diarrhea with Saccharomyces boulardii in infants

Naflesia B O Corrêa  1 , Francisco J Penna, Fátima M L S Lima, Jacques R Nicoli, Luciano A P Filho
Affiliations
Randomized Controlled Trial

Treatment of acute diarrhea with Saccharomyces boulardii in infants

Naflesia B O Corrêa et al. J Pediatr Gastroenterol Nutr. 2011 Nov.

Abstract

Objective: The aim of the study was to determine whether an oral treatment with a commercial pharmaceutical product containing Saccharomyces boulardii would reduce the duration of diarrhea in infants with acute diarrhea.

Patients and methods: In the present double-blind, placebo-controlled study, 186 infants, 6 to 48 months old and hospitalized within 72 hours after the onset of acute diarrhea in 2 hospitals in Goiânia, Goiás, Brazil, were randomly assigned to receive twice per day for 5 days 200 mg of a commercial pharmaceutical product containing 4 × 10 viable cells of S boulardii or a placebo. Stool samples were submitted to search for rotavirus. Among the 176 infants who completed the trial, those treated with S boulardii (90) showed a reduction in diarrhea duration (P < 0.05) when compared with the placebo group (86).

Results: The present study shows a reduction in diarrhea duration when S boulardii was given to children within 72 hours after the onset of acute diarrhea.

Conclusions: The present study suggests a complementary treatment of acute diarrhea in infants with daily oral doses of S boulardii.

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