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Review
. 2011 Jul 7;11(8):558-72.
doi: 10.1038/nrc3090.

Cyclin D as a therapeutic target in cancer

Elizabeth A Musgrove  1 , C Elizabeth Caldon, Jane Barraclough, Andrew Stone, Robert L Sutherland
Affiliations
Review

Cyclin D as a therapeutic target in cancer

Elizabeth A Musgrove et al. Nat Rev Cancer. .

Abstract

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how might the patient subgroups that are most likely to benefit be identified?

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