New perspectives on rodent models of advanced paternal age: relevance to autism

doi:10.3389/fnbeh.2011.00032

. 2011 Jun 23:5:32.

doi: 10.3389/fnbeh.2011.00032. eCollection 2011.

New perspectives on rodent models of advanced paternal age: relevance to autism

Claire J Foldi¹, Darryl W Eyles, Traute Flatscher-Bader, John J McGrath, Thomas H J Burne

Affiliations

PMID: 21734873
PMCID: PMC3124931
DOI: 10.3389/fnbeh.2011.00032

New perspectives on rodent models of advanced paternal age: relevance to autism

Claire J Foldi et al. Front Behav Neurosci. 2011.

. 2011 Jun 23:5:32.

doi: 10.3389/fnbeh.2011.00032. eCollection 2011.

Authors

Claire J Foldi¹, Darryl W Eyles, Traute Flatscher-Bader, John J McGrath, Thomas H J Burne

Affiliation

¹ Queensland Brain Institute, The University of Queensland St Lucia, QLD, Australia.

PMID: 21734873
PMCID: PMC3124931
DOI: 10.3389/fnbeh.2011.00032

Abstract

Offspring of older fathers have an increased risk of various adverse health outcomes, including autism and schizophrenia. With respect to biological mechanisms for this association, there are many more germline cell divisions in the life history of a sperm relative to that of an oocyte. This leads to more opportunities for copy error mutations in germ cells from older fathers. Evidence also suggests that epigenetic patterning in the sperm from older men is altered. Rodent models provide an experimental platform to examine the association between paternal age and brain development. Several rodent models of advanced paternal age (APA) have been published with relevance to intermediate phenotypes related to autism. All four published APA models vary in key features creating a lack of consistency with respect to behavioral phenotypes. A consideration of common phenotypes that emerge from these APA-related mouse models may be informative in the exploration of the molecular and neurobiological correlates of APA.

Keywords: advanced paternal age; autism; behavior; epigenetics; mouse.

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[1] Alter M. D., Gilani A. I., Champagne F. A., Curley J. P., Turner J. B., Hen R. (2009). Paternal transmission of complex phenotypes in inbred mice. Biol. Psychiatry 66, 1061–106610.1016/j.biopsych.2009.05.026 - DOI - PMC - PubMed

[2] Alter M. D., Gilani A. I., Champagne F. A., Curley J. P., Turner J. B., Hen R. (2009). Paternal transmission of complex phenotypes in inbred mice. Biol. Psychiatry 66, 1061–106610.1016/j.biopsych.2009.05.026 - DOI - PMC - PubMed

[3] Auroux M. (1983). Decrease of learning capacity in offspring with increasing paternal age in the rat. Teratology 27, 141–14810.1002/tera.1420270202 - DOI - PubMed

[4] Auroux M. (1983). Decrease of learning capacity in offspring with increasing paternal age in the rat. Teratology 27, 141–14810.1002/tera.1420270202 - DOI - PubMed

[5] Baron C. A., Tepper C. G., Liu S. Y., Davis R. R., Wang N. J., Schanen N. C., Gregg J. P. (2006). Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Hum. Mol. Genet. 15, 853–86910.1093/hmg/ddl004 - DOI - PubMed

[6] Baron C. A., Tepper C. G., Liu S. Y., Davis R. R., Wang N. J., Schanen N. C., Gregg J. P. (2006). Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Hum. Mol. Genet. 15, 853–86910.1093/hmg/ddl004 - DOI - PubMed

[7] Berg J. S., Brunetti-Pierri N., Peters S. U., Kang S. H. L., Fong C. T., Salamone J., Freedenberg D., Hannig V. L., Prock L. A., Miller D. T., Raffalli P., Harris D. J., Erickson R. P., Cunniff C., Clark G. D., Blazo M. A., Peiffer D. A., Gunderson K. L., Sahoo T., Patel A., Lupski J. R., Beaudet A. L., Cheung S. W. (2007). Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet. Med. 9, 427–44110.1097/GIM.0b013e3180986192 - DOI - PubMed

[8] Berg J. S., Brunetti-Pierri N., Peters S. U., Kang S. H. L., Fong C. T., Salamone J., Freedenberg D., Hannig V. L., Prock L. A., Miller D. T., Raffalli P., Harris D. J., Erickson R. P., Cunniff C., Clark G. D., Blazo M. A., Peiffer D. A., Gunderson K. L., Sahoo T., Patel A., Lupski J. R., Beaudet A. L., Cheung S. W. (2007). Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet. Med. 9, 427–44110.1097/GIM.0b013e3180986192 - DOI - PubMed

[9] Bray I., Gunnell D., Smith G. D. (2006). Advanced paternal age: how old is too old? J. Epidemiol. Community Health 60, 851–85310.1136/jech.2005.045179 - DOI - PMC - PubMed

[10] Bray I., Gunnell D., Smith G. D. (2006). Advanced paternal age: how old is too old? J. Epidemiol. Community Health 60, 851–85310.1136/jech.2005.045179 - DOI - PMC - PubMed

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New perspectives on rodent models of advanced paternal age: relevance to autism

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New perspectives on rodent models of advanced paternal age: relevance to autism

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