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. 2011 Aug 21;47(31):8961-3.
doi: 10.1039/c1cc13132j. Epub 2011 Jul 6.

Automated solid phase synthesis of teichoic acids

Wouter F J Hogendorf  1 , Nico Meeuwenoord, Herman S Overkleeft, Dmitri V Filippov, Diana Laverde, Andrea Kropec, Johannes Huebner, Gijsbert A Van der Marel, Jeroen D C Codée
Affiliations

Automated solid phase synthesis of teichoic acids

Wouter F J Hogendorf et al. Chem Commun (Camb). .

Abstract

This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length-activity relationship and indicated a promising candidate for future vaccine development.

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