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. 1978 Dec 1;175(3):1147-50.
doi: 10.1042/bj1751147.

A new carbon monoxide-induced complex of cytochrome c oxidase

A new carbon monoxide-induced complex of cytochrome c oxidase

P Nicholls. Biochem J. .

Abstract

Cytochrome c oxidase isolated from ox heart forms a complex in the presence of millimolar concentrations of CO with absorption bands at 606, 565 and 435 nm (difference spectrum), distinct from both ferrocytochrome a and the classical 590nm carbon-monoxyferrocytochrome a3. This species, which closely resembles Compound C, the derivative formed on photolysis and oxygenation of mixed-valence cytochrome a3+a32+CO, may represent a cytochrome a32+CO complex in which the associated ('invisible') copper is still oxidized.

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