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. 2011;36(3):109-15.
doi: 10.3109/07435800.2011.580443.

Evaluation of insulin-like growth factor-1 in Indian growth hormone-deficient children on growth hormone therapy

Veena H Ekbote  1 , Vaishakhi T Rustagi, Vaman V Khadilkar, Anuradha V Khadilkar, Shashi A Chiplonkar
Affiliations

Evaluation of insulin-like growth factor-1 in Indian growth hormone-deficient children on growth hormone therapy

Veena H Ekbote et al. Endocr Res. 2011.

Abstract

Objective: To evaluate the impact of recombinant human growth hormone therapy (GHT) on serum insulin-like growth factor 1 (IGF-1) concentrations in Indian children with growth hormone deficiency.

Methods: Data on anthropometry and serum IGF-1 concentrations were collected from 28 growth hormone-deficient prepubertal children (8.6 ± 2.9 years) on growth hormone therapy, 6 monthly over the period of 2 years.

Results: Height z-scores showed a steady increase from baseline to 24 months. However, IGF-1 z-scores showed a plateau after the first 6 months and then a small dip followed by a rise. The pattern of increase of IGF-1 z-scores was dissimilar to that of the height z-scores.

Conclusion: The change in serum IGF-1 z-scores in response to GHT in Indian children may not be a good indicator for monitoring growth hormone responsiveness.

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