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Comparative Study
. 2011 Jul 7:7:11.
doi: 10.1186/1746-160X-7-11.

The effects of Bleomycin A5 on infantile maxillofacial haemangioma

Quan-feng Luo  1 , Fu-yun Zhao
Affiliations
Comparative Study

The effects of Bleomycin A5 on infantile maxillofacial haemangioma

Quan-feng Luo et al. Head Face Med. .

Abstract

Objective: To examine the effects of bleomycin A5 on infantile maxillofacial haemangiomas.

Methods: Bleomycin A5 was given by multiple intralesinoal injections and the dosage was given according to the age of the patient and size of the lesion. Parts of patients were accompanied by prednisone treatment (2-5 mg/kg, po, QOD.

Results: All the haemangiomas involutes completely after treated with bloemycin A5 with better recovery of skin color and less scar forming in small haemangiomas.

Conclusion: Infantile haemangioma could be effectively treated with bleomycin A5 without serious side effects.

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Figures

Figure 1
Figure 1
Age of first consultation.
Figure 2
Figure 2
Distribution of hemangioma size.
Figure 3
Figure 3
This boy presented at 40 days of age with a hemangioma in the left parotid area. Bleomycin A5 was given once every 4 weeks for a total of 7 treatments.
Figure 4
Figure 4
The hemangioma had completely involuted one year later. The overall response was Scale II.
Figure 5
Figure 5
This girl had a hemangioma at the center of her face that involved the nose, right eyelid, and bilateral medial canthi.
Figure 6
Figure 6
The hemangioma involuted one year and five months after bleomycin treatment. The overall response was Scale II.
Figure 7
Figure 7
A large hemangioma was present on the left face, involving the eyelid, nose, and upper lip. Bleomycin A5 was given once a month for 7 months. Four months later, treatment was resumed again. The total treatment period was 2 years and 4 months.
Figure 8
Figure 8
Three years later, the hemangioma had completely involuted, with few scars, the overall was Scale I.
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