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Review
. 2011;58(1):297-311.
doi: 10.1016/j.yapd.2011.03.011.

Neuroblastoma

Nadja C Colon  1 , Dai H Chung
Affiliations
Review

Neuroblastoma

Nadja C Colon et al. Adv Pediatr. 2011.
No abstract available

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Figures

Figure 1
Figure 1
International Neuroblastoma Risk Group (INRG) Classification. L1, localized tumor confined to one body compartment and with absence of image-defined risk factors (IDRFs); L2, locoregional tumor with presence of one or more IDRFs; M, distant metastatic disease (except stage MS); MS, metastatic disease confined to skin, liver and/or bone marrow in children < 18 months of age; EFS, event-free survival (From Cohn et al, The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report.J Clin Onc; 2009; Fig. 2, p.295; with permission).
Figure 2
Figure 2
Effects of GRP-receptor knockdown on neuroblastoma metastasis in vivo. Spleen injection liver metastasis murine model was used using human neuroblastoma BE(2)-C cells transfected with pEGFP/shGRP-R (silenced GRP receptors) or pEGFP/shCON (controls). (A) Representative images of livers from mice injected with BE(2)-C/GFP/shGRP-R (short-hairpin silenced GRP-receptors) and control cells (shCON). Silencing of GRP-receptors (shGRP-R; right column) attenuated liver metastasis of BE(2)-C tumors. Quantitative analysis of liver weight relative to body weight (* p<0.05 vs. shCON) shows significantly less weight in GRP-R silenced group (B) Representative H&E-stained sections of livers from mice injected with BE(2)-C/GFP/shCON (controls; upper) and BE(2)-C/GFP/shGRP-R (GRP receptor silenced; lower) cells. Extensive liver metastases are seen in mice from constitutive GRP-receptor expressing BE(2)-C cells (upper). (Adapted from Qiao et al, Proc Natl Acad Sci 2008; Fig. 6, p.12895. Copyright2008 National Academy of Sciences, U.S.A).
See this image and copyright information in PMC

References

    1. Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematol Oncol Clin North Am. 2010;24:65–86. - PubMed
    1. Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362:2202–2211. - PMC - PubMed
    1. Esiashvili N, Anderson C, Katzenstein HM. Neuroblastoma. Curr Probl Cancer. 2009;33:333–360. - PubMed
    1. Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003;3:203–216. - PubMed
    1. London WB, Matthay KK, Ambros PF, et al. Clinical and biological features predictive of survival after relapse of neuroblastoma: A study from the International Neuroblastoma (NB) Risk Group (INRG) Database. J Clin Oncol. 2010;28:9518.

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