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Review
. 2011 Jun;31(6):2283-90.

Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy

Farshad Nassiri  1 , Michael D Cusimano, Bernd W Scheithauer, Fabio Rotondo, Alessandra Fazio, George M Yousef, Luis V Syro, Kalman Kovacs, Ricardo V Lloyd
Affiliations
  • PMID: 21737653
Review

Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy

Farshad Nassiri et al. Anticancer Res. 2011 Jun.

Abstract

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.

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