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Comment
. 2011 Jul 7;17(7):776.
doi: 10.1038/nm0711-776a.

Bronchodilator activity of bitter tastants in human tissue

Maria G Belvisi, Nicole Dale, Mark A Birrell, Brendan J Canning
Comment

Bronchodilator activity of bitter tastants in human tissue

Maria G Belvisi et al. Nat Med. .
No abstract available

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Comparison of chloroquine- and isoprenaline-induced relaxation of isolated human airway smooth muscle. (a,b) Relaxant responses of airway tissue induced by increasing concentrations of isoproterenol or chloroquine in tissues that were precontracted with histamine (a) or carbachol (b). Maximal tissue relaxation was assessed by treatment with papaverine (100 μM). Data shown are from experiments using samples from two separate lung samples and are expressed as the percentage of maximum relaxation to papaverine (100 μm). tension. (c,d) Representative traces from an experiment done on bronchial strips that were pre-contracted with acetylcholine (ACh; 0.1 mM) and then treated with vehicle (c) or 10 μM isoproterenol (d). Maximal tissue relaxation was induced by papaverine (100 μM). See Supplementary Methods for additional details.
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