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Case Reports
. 2011 Feb;23(1):73-5.
doi: 10.5021/ad.2011.23.1.73. Epub 2011 Feb 28.

Pigmented mammary paget disease with reticulated features: a rare variant of mammary paget disease

Eun Ah Lee  1 , Hei Sung Kim, Hyung Ok Kim, Young Min Park
Affiliations
Case Reports

Pigmented mammary paget disease with reticulated features: a rare variant of mammary paget disease

Eun Ah Lee et al. Ann Dermatol. 2011 Feb.

Abstract

Pigmented mammary Paget disease (PMPD) is a rare subtype of mammary Paget disease that presents as a hyperpigmented patch or plaque over the areola and nipple. We herein report on an unusual case of PMPD with reticulated features in a 98-year-old female. The histology showed intraepidermal pagetoid cells containing melanin pigments without any underlying intraductal carcinoma.

Keywords: Pigmented mammary Paget disease; Reticulated pattern.

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Figures

Fig. 1
Fig. 1
Dark brownish colored reticulated plaque on the left breast and nipple.
Fig. 2
Fig. 2
Large clear cells with vesicular nuclei are dispersed in the suprabasal layers of the epidermis. Some clear cells contain intracytoplasmic melanin pigments (A: H&E, ×400). Immunohistochemical staining of Paget cells (B: anticytokeratin 7, C: CEA, D: S-100 protein and E: HMB-45, ×400).
See this image and copyright information in PMC

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