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Comparative Study
. 2011:2011:807929.
doi: 10.1155/2011/807929. Epub 2011 Jun 16.

Comparison of cell proliferation, protein, and glucose metabolism in musculoskeletal tumors in a PET study

Mei Tian  1 , Hong Zhang, Keigo Endo
Affiliations
Comparative Study

Comparison of cell proliferation, protein, and glucose metabolism in musculoskeletal tumors in a PET study

Mei Tian et al. J Biomed Biotechnol. 2011.

Abstract

¹¹C-choline and ¹⁸F-FAMT are known to correlate with tumor cell proliferation and amino acid metabolism. We investigated the ability of ¹¹C-Choline and ¹⁸F-FAMT PET in diagnosis of musculoskeletal tumors in thirty-six patients in comparison of ¹⁸F-FDG PET. ¹¹C-Choline and ¹⁸F-FDG PET were positive in all the malignant tumors (n = 13), whereas ¹⁸F-FAMT was positive in 11 tumors. The mean SUVs for malignant tumors were significantly higher than those for benign lesions in all three tracers imaging. A moderate correlation was found between ¹¹C-Choline and ¹⁸F-FDG (r = 0.540, P < .05), or ¹⁸F-FAMT and FDG (r = 0.596, P < .05). The diagnostic sensitivity and specificity for malignancy were 91.7% and 71.4%, respectively, using ¹¹C-choline with a SUV cut-off of 2.69. The sensitivity and specificity of ¹⁸F-FAMT for malignancy were 66.7% and 85.7%, respectively, using a SUV cut-off of 1.26. For ¹⁸F-FDG, using a SUV cut-off of 2.77, the sensitivity and specificity were 83.3% and 71.4%, respectively. According to ROC analysis, the ROC curves for ¹¹C-Choline, ¹⁸F-FAMT, and ¹⁸F-FDG were 0.855, 0.734, and 0.847, respectively. ¹¹C-Choline PET is superior in the visualization of musculoskeletal tumors with high contrast imaging, whereas the combination of ¹⁸F-FAMT and ¹⁸F-FDG PET provides valuable information for the preoperative planning in patients with musculoskeletal tumors.

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Figures

Figure 1
Figure 1
A 43-year-old female with osteosarcoma. 18F-FDG (SUV = 6.0) (a), 18F-FAMT (SUV = 2.0) (b), and 11C-choline (SUV = 9.3) (c) demonstrated high tracer uptake in the tumor of the left tibia, which corresponded to the area that was enhanced on MRI image (d).
Figure 2
Figure 2
A 53-year-old male with giant cell tumor in the left knee. 18F-FDG (SUV = 4.36) (a) and 11C-choline (SUV = 4.20) (c) demonstrated high tracer uptake in the tumor of the left knee, whereas 18F-FAMT (SUV = 0.65) (b) showed mild uptake, which corresponded to the area that was shown on MRI image (d).
Figure 3
Figure 3
A 60-year-old male with neurofibroma in the left femur. 18F-FDG (SUV = 3.49) (a), 18F-FAMT (SUV = 1.40) (b), and 11C-choline (SUV = 5.10) (c) showed clear tracer uptake in the tumor of the left femur, which corresponded to the area that was enhanced on MRI image (d).
Figure 4
Figure 4
Standardized uptake value (SUV) of 18F-FDG, 18F-FAMT, and 11C-choline in malignant and benign lesions. 18F-FDG, 18F-FAMT, and 11C-choline revealed significant higher SUV in malignant lesions than in benign lesions (P < .002, P < .02, and P < .001, resp.). Differences of tumor SUVs between 18F-FDG and 11C-choline were not significant in both malignant and benign lesions, whereas both 18F-FDG and 11C-choline SUVs were significantly higher than that of 18F-FAMT.
Figure 5
Figure 5
Relationship among 18F-FDG, 18F-FAMT, and 11C-choline uptakes in musculoskeletal tumors. Moderate correlation was observed between 11C-choline uptake and 18F-FDG uptake, and 18F-FAMT and 18F-FDG in all lesions.
Figure 6
Figure 6
Comparison among 18F-FDG, 18F-FAMT, and 11C-choline PET in differential diagnosis between malignant tumors and benign lesions by ROC analysis in musculoskeletal tumors.
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References

    1. Jadvar H, Gamie S, Ramanna L, Conti PS. Musculoskeletal system. Seminars in Nuclear Medicine. 2004;34(4):254–261. - PubMed
    1. Verstraete KL, VanderWoude HJ, Hogendoorn PC, DeDeene Y, Kunnen M, Bloem JL. Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: basic principles and clinical applications. Journal of Magnetic Resonance Imaging. 1996;5:311–321. - PubMed
    1. Zhang H, Yoshikawa K, Tamura K, et al. 11C-methionine positron emission tomography and survival in patients with bone and soft tissue sarcomas treated by carbon ion radiotherapy. Clinical Cancer Research. 2004;10(5):1764–1772. - PubMed
    1. Tian M, Zhang H, Oriuchi N, Higuchi T, Endo K. Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors. European Journal of Nuclear Medicine and Molecular Imaging. 2004;31(8):1064–1072. - PubMed
    1. Tian M, Zhang H, Nakasone Y, Mogi K, Endo K. Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. European Journal of Nuclear Medicine and Molecular Imaging. 2004;31(1):5–12. - PubMed

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