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Review
. 2011 Jun;12(6):467-71.
doi: 10.1038/ni.2038.

Origins of CD4(+) effector and central memory T cells

Marion Pepper  1 , Marc K Jenkins
Affiliations
Review

Origins of CD4(+) effector and central memory T cells

Marion Pepper et al. Nat Immunol. 2011 Jun.

Abstract

Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T(FH) cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.

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Figures

Figure 1
Figure 1. Model for simultaneous generation of Tem and Tcm cells
See text for description.
See this image and copyright information in PMC

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