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Case Reports
. 2011 Aug;49(7):691-3.
doi: 10.3109/15563650.2011.592838. Epub 2011 Jul 8.

Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone)

Adrian Derungs  1 , Simeon Schietzel, Markus R Meyer, Hans H Maurer, Stephan Krähenbühl, Matthias E Liechti
Affiliations
Case Reports

Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone)

Adrian Derungs et al. Clin Toxicol (Phila). 2011 Aug.

Abstract

Context: Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone.

Case: We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. Naphyrone was detected in the patient's plasma by gas chromatography with mass spectrometry at concentrations of 0.03 and 0.02 mg/L, 40 and 60 h after drug intake, respectively.

Discussion: Based on the present case report and user web-reports, as well as on the chemical structure and pharmacological characteristics, naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity.

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