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. 2011 Aug;217(2):543-8.
doi: 10.1016/j.atherosclerosis.2011.05.035. Epub 2011 Jun 12.

Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study

Masumi Ai  1 , Seiko Otokozawa, Bela F Asztalos, Charles C White, L Adrienne Cupples, Katsuyuki Nakajima, Stefania Lamon-Fava, Peter W Wilson, Yuji Matsuzawa, Ernst J Schaefer
Affiliations

Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study

Masumi Ai et al. Atherosclerosis. 2011 Aug.

Abstract

Objective: Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk.

Methods and results: Plasma adiponectin levels were measured in 3188 male and female participants from cycle 6 of the Framingham offspring Study (mean age: 57 years in both men and women; BMI: 28.5 kg/m(2) in men and 27.3 kg/m(2) in women), using a novel fully automated assay. Plasma adiponectin levels (median [25th percentile, 75th percentile]) were significantly higher in female than in male CHD-free subjects (14.8 [10.7,20.5] μg/ml versus 9.0 [7.0,12.2] μg/ml, p<0.001). Participants were followed for a mean of 7.5 years. After adjustment for age, BMI, smoking status, systolic blood pressure, treatment for hypertension, diabetes, use of cholesterol-lowering medication, total cholesterol level, high-density lipoprotein cholesterol level, and C-reactive protein levels, a higher plasma adiponectin level was a significant predictor of lower risk of future CHD events (n=117) in men (HR 0.49, p<0.0022). A similar trend was observed in women, but was no longer significant after multivariate adjustments.

Conclusions: Our data indicate that plasma adiponectin levels are an independent predictor of CHD in Caucasian men initially free of CHD.

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Figures

Figure 1
Figure 1
Kaplan-Meyer curves for the baseline plasma adiponectin levels and the cause of cardiovascular diseases in men after adjusted for age. The bottom quartile of plasma adiponectin levels had significantly higher event rates than the top 3 quartiles.
Figure 2
Figure 2
Kaplan-Meyer curves for the baseline plasma adiponectin levels and the cause of cardiovascular diseases in women after adjusted for age. The bottom quartile of plasma adiponectin levels had significantly higher event rates than the top 3 quartiles.
See this image and copyright information in PMC

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