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. 1990 Dec;10(12):6759-64.
doi: 10.1128/mcb.10.12.6759-6764.1990.

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei

T Pace  1 , M Ponzi, E Dore, C Janse, B Mons, C Frontali
Affiliations

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei

T Pace et al. Mol Cell Biol. 1990 Dec.

Abstract

During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.

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References

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