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Comment
. 2011 Jul 12;20(1):1-2.
doi: 10.1016/j.ccr.2011.06.025.

The role of TET2 in hematologic neoplasms

Linda Holmfeldt  1 , Charles G Mullighan
Affiliations
Comment

The role of TET2 in hematologic neoplasms

Linda Holmfeldt et al. Cancer Cell. .

Abstract

TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-function mutations in myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia. In this issue of Cancer Cell, two studies show that inactivation of Tet2 enhances hematopoietic stem cell self renewal and promotes the development of myeloproliferative disorders.

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