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Review
. 2011 Sep;6(5):379-84.
doi: 10.1097/COH.0b013e3283499d63.

Myeloid dendritic cells in HIV-1 infection

Nina Derby  1 , Elena Martinelli, Melissa Robbiani
Affiliations
Review

Myeloid dendritic cells in HIV-1 infection

Nina Derby et al. Curr Opin HIV AIDS. 2011 Sep.

Abstract

Purpose of review: Myeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread and at the same time are critical for recognizing HIV-1 and initiating immune responses to fight infection. Notably, their immunostimulatory capabilities can be harnessed to design better HIV-1 vaccines. In this review, advances in these areas of mDC-HIV-1 interactions are summarized.

Recent findings: New insights into HIV-1-induced dysfunction of mDCs and dysfunctional mDC effects on other cell types, as well as novel mechanisms of viral sensing by mDCs and their evasion by HIV-1, have been uncovered. These results emphasize the importance of mDCs in protection against HIV-1 infection. Targeting mDCs with vaccines and tailored adjuvants may improve the quality and anatomical location of elicited immune responses.

Summary: Understanding the multiplicity of HIV-1-dendritic cell interactions together with the numerous advances in targeted therapy and vaccination will help in the rational design of approaches to treat and block infection.

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