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. 1990 Dec 15;46(6):976-84.
doi: 10.1002/ijc.2910460605.

Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis

K Falk  1 , I Ernberg, R Sakthivel, J Davis, B Christensson, J Luka, M Okano, H L Grierson, G Klein, D T Purtilo
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Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis

K Falk et al. Int J Cancer. .

Abstract

We assessed 33 lymphoid tissues from 15 patients, including 7 with X-linked lymphoproliferative disease (XLP) and 8 patients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immunophenotype and expressed Epstein-Barr virus (EBV)-encoded proteins characteristic of either EBV-immortalized lymphoblastoid cell lines (LCL) or EBV-carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL-like, and in 2 cases they were monoclonal, malignant lymphoma-like.

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