doi: 10.1016/j.fitote.2011.06.007.
Epub 2011 Jul 2.
A new 1,3-diketofriedelane triterpene from Salacia verrucosa
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- PMID: 21745551
- DOI: 10.1016/j.fitote.2011.06.007
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A new 1,3-diketofriedelane triterpene from Salacia verrucosa
Fitoterapia.
2011 Oct.
Abstract
A new 1,3-diketofriedelane triterpene, 21α-hydroxyfriedelane-1,3-dione (1) together with six known friedelane triterpenes, 30-hydroxyfriedelane-1,3-dione (2), friedelane-1,3-dione (3), 26-hydroxyfriedelane-1,3-dione (4), friedelin (5), 21α-hydroxy-D:A-friedo-olean-3-one (6) and kokoonol (7), were isolated from the stems of Salacia verrucosa (Celastraceae). The structures of these triterpenes were characterized by spectroscopic methods (IR, MS and NMR). Compound 3 was strongly cytotoxic against SW620 cell line, whereas compounds 4 and 6 were moderately active against SW620, HepG2 and KATO-III cancer cell lines.
Copyright © 2011 Elsevier B.V. All rights reserved.
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