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Comment
. 2011 Jul 14;71(1):4-6.
doi: 10.1016/j.neuron.2011.06.033.

Leptin grows up and gets a neural network

Roger D Cone  1 , Richard B Simerly
Affiliations
Comment

Leptin grows up and gets a neural network

Roger D Cone et al. Neuron. .

Abstract

Studies seeking a dominant site of action for the hormone leptin have focused on leptin receptor-expressing neuropeptidergic neurons. In this issue, Vong et al. show that leptin regulates energy homeostasis predominantly via a distributed network of GABAergic neurons.

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Figures

Figure 1
Figure 1. Leptin Regulates the ARC to PVN Circuit Via a Distributed Network of Predominantly GABAergic Neurons
Diagram shows one example of the hundreds of POMC and NPY/AgRP projections throughout the CNS, and the network of leptin receptor expressing GABAergic neurons controlling this circuit. Major sites of leptin-responsive GABAergic neurons identified in Vong et al. include ARC, LH, and DMH. Note that most of the GABAergic and glutamatergic inputs to the POMC and NPY/AgRP neurons remain undefined. Target neurons in the PVN are highly heterogeneous, and are also regulated by a complex network of GABAergic and glutamatergic inputs.
See this image and copyright information in PMC

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References

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