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. 2011 Sep;55(9):4416-9.
doi: 10.1128/AAC.00217-11. Epub 2011 Jul 11.

In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin

Evgeny A Idelevich  1 , Christof von Eiff, Alexander W Friedrich, Domenico Iannelli, Guoqing Xia, Georg Peters, Andreas Peschel, Ingrid Wanninger, Karsten Becker
Affiliations

In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin

Evgeny A Idelevich et al. Antimicrob Agents Chemother. 2011 Sep.

Abstract

Antistaphylococcal activity of the novel chimeric endolysin PRF-119 was evaluated with the microdilution method. The MIC(50) and MIC(90) of 398 methicillin-susceptible Staphylococcus aureus isolates were 0.098 μg/ml and 0.391 μg/ml, respectively (range, 0.024 to 0.780 μg/ml). Both the MIC(50) and MIC(90) values of 776 methicillin-resistant S. aureus isolates were 0.391 μg/ml (range, 0.024 to 1.563 μg/ml). All 192 clinical isolates of coagulase-negative staphylococci exhibited MIC values of >50 μg/ml. In conclusion, PRF-119 exhibited very good activity specifically against S. aureus.

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References

    1. Ammerlaan H. S., Kluytmans J. A., Wertheim H. F., Nouwen J. L., Bonten M. J. 2009. Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review. Clin. Infect. Dis. 48:922–930 - PubMed
    1. Arthington-Skaggs B. A., et al. 2002. Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Candida isolates. Antimicrob. Agents Chemother. 46:2477–2481 - PMC - PubMed
    1. Becker K., et al. 2005. Thermonuclease gene as a target for specific identification of Staphylococcus intermedius isolates: use of a PCR-DNA enzyme immunoassay. Diagn. Microbiol. Infect. Dis. 51:237–244 - PubMed
    1. Capparelli R., et al. 2010. Bacteriophage-resistant Staphylococcus aureus mutant confers broad immunity against staphylococcal infection in mice. PLoS One 5:e11720. - PMC - PubMed
    1. Coates T., Bax R., Coates A. 2009. Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects. J. Antimicrob. Chemother. 64:9–15 - PMC - PubMed

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