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Review
. 2011;12(6):3536-52.
doi: 10.3390/ijms12063536. Epub 2011 Jun 3.

Recombinant cytokines from plants

Agnieszka Sirko  1 , Tomas Vaněk, Anna Góra-Sochacka, Patrycja Redkiewicz
Affiliations
Review

Recombinant cytokines from plants

Agnieszka Sirko et al. Int J Mol Sci. 2011.

Abstract

Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.

Keywords: cytokines; interleukins; molecular farming; pharmaceutical proteins; plant-based production systems; transgenic plants.

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Figures

Figure 1
Figure 1
The families of cytokines (according to the Kyoto Encyclopedia of Genes and Genomes [4]).
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References

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