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. 2011;9(6):1157-1165.
doi: 10.3390/md9061157. Epub 2011 Jun 23.

Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis

Anna Aiello  1 , Ernesto Fattorusso  1 , Concetta Imperatore  1 , Carlo Irace  2 , Paolo Luciano  3 , Marialuisa Menna  1 , Rita Santamaria  2 , Rocco Vitalone  1
Affiliations

Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis

Anna Aiello et al. Mar Drugs. 2011.

Abstract

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.

Keywords: alkaloids; ascidians; bioactive molecules; cytotoxic activity; natural products.

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Figures

Figure 1
Figure 1
Structures of compounds 1–4.
Figure 2
Figure 2
Structures of polycarpine (5) and related compounds (6–8).
Scheme 1.
Scheme 1.
Equilibrium of compound 2 with the guanidinic open form.
See this image and copyright information in PMC

References

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