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. 2011:2011:921814.
doi: 10.1155/2011/921814. Epub 2011 May 26.

Systematic review of primary hyperparathyroidism in India: the past, present, and the future trends

P V Pradeep  1 , B Jayashree, Anjali Mishra, S K Mishra
Affiliations

Systematic review of primary hyperparathyroidism in India: the past, present, and the future trends

P V Pradeep et al. Int J Endocrinol. 2011.

Abstract

Primary hyperparathyroidism (PHPT) has become an asymptomatic disease in the Western world with the introduction of routine calcium screening. However, the same phenomenon is not observed in India. We have now systematically reviewed the status of PHPT in India. While there is a paucity of literature on PHPT from India when compared to Western countries, some information can be gleaned upon. Most patients present with symptomatic disease whereas very few are screen-detected cases (bone disease 77%, renal disease 36%, and 5.6% asymptomatic). Mean calcium, parathyroid hormone (PTH), and alkaline phosphate levels are high while Vitamin D levels are low. The average parathyroid gland weight is large and the majority being parathyroid adenomas (89.1%). Hungry bone syndrome (HBS) is common in the postoperative period. The disease-related mortality rate is 7.4%, recurrence 4.16%, and persistent disease 2.17%. We suggest that dedicated efforts are needed to pick up asymptomatic disease in India by methods like incorporating calcium estimation in the routine health check-up programs.

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Figures

Figure 1
Figure 1
Decade wise publications on PHPT from India.
Figure 2
Figure 2
Publications on PHPT: India versus others.
Figure 3
Figure 3
(a) Reveals advanced bone disease with fractures of femur (fixed by rod and nails) and (b) the MIBI scan in a patient with parathyroid adenoma.
Figure 4
Figure 4
Advanced bone disease (OFC) excised and replaced with humerus prosthesis in a patient with PHPT where the diagnosis was missed.
See this image and copyright information in PMC

References

    1. AACE/AAES position statement. Endocrine Practice. 2005;11(1):50–54. - PubMed
    1. Bilezikian JP, Silverberg SJ. Asymptomatic primary hyperparathyroidism. The New England Journal of Medicine. 2004;350(17):1746–1751. - PubMed
    1. Lundgren E, Rastad J. Surgical Endocrinology. Philadelphia, Pa, USA: Lippincott Williams and Wilkins; 2001. Diagnosis, natural history and intervention in sporadic primary hyperparathyroidism; pp. 137–162.
    1. Mishra SK, Agarwal G, Kar DK, Gupta SK, Mithal A, Rastad J. Unique clinical characteristics of primary hyperparathyroidism in India. British Journal of Surgery. 2001;88(5):708–714. - PubMed
    1. Pradeep PV, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK. Long-term outcome after parathyroidectomy in patients with advanced primary hyperparathyroidism and associated vitamin D deficiency. World Journal of Surgery. 2008;32(5):829–835. - PubMed

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