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. 2011:2011:405139.
doi: 10.1155/2011/405139. Epub 2011 Apr 3.

Effects of orally administered lactoferrin and lactoperoxidase-containing tablets on clinical and bacteriological profiles in chronic periodontitis patients

Eiju Shimizu  1 , Tetsuo Kobayashi, Hiroyuki Wakabayashi, Koji Yamauchi, Keiji Iwatsuki, Hiromasa Yoshie
Affiliations

Effects of orally administered lactoferrin and lactoperoxidase-containing tablets on clinical and bacteriological profiles in chronic periodontitis patients

Eiju Shimizu et al. Int J Dent. 2011.

Abstract

This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group, n = 37) or control tablets (control group, n = 35) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study (P < .05). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study.

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Figures

Figure 1
Figure 1
Flowchart of participants through each stage of the randomized trial.
Figure 2
Figure 2
Effect of the test tablet on bovine and human LF levels in saliva and gingival crevicular fluid (GCF). Saliva levels of bovine LF (a), GCF levels of bovine LF (b), Saliva levels of human LF (c), and GCF levels of human LF (d) were measured at baseline, 1 W, 4 W, 12 W. Values represent the mean ± standard error. GCF levels of bovine and human LF were assessed in two teeth with chronic periodontitis per subject. *Significant difference between the test and control groups, as identified by Student's t-test (P < .05).
Figure 3
Figure 3
Effects of the test tablet on bacterial number and endotoxin levels in saliva, subgingival plaque, and gingival crevicular fluid (GCF). Total bacterial number in saliva (a), total bacterial number in subgingival plaque (b), P. gingivalis number in saliva (c), P. gingivalis number in subgingival plaque (d), saliva levels of endotoxin (e), and GCF levels of endotoxin (f) were measured at baseline, 1 W, 4 W, 12 W. Values represent the mean ± standard error. The number of total bacteria and P. gingivalis in subgingival plaque and GCF levels of endotoxin were assessed in two teeth with chronic periodontitis per subject.*Significant difference between the test and control groups, as identified by Student's t-test (P < .05).
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