Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2011 Sep;28(9):815-20.
doi: 10.1007/s10815-011-9604-y. Epub 2011 Jul 12.

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Ozlem Gun Eryilmaz  1 , Aysun Devran, Esma Sarikaya, Fatma Nur Aksakal, Leyla Mollamahmutoğlu, Nedim Cicek
Affiliations
Randomized Controlled Trial

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Ozlem Gun Eryilmaz et al. J Assist Reprod Genet. 2011 Sep.

Abstract

Purpose: We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.

Methods: A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.

Results: Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.

Conclusion: IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow diagram of the patients who received melatonin and not received melatonin
See this image and copyright information in PMC

References

    1. Pal L, Bevilacqua K, Zeitlian G, Shu J, Santoro N. Implications of diminished ovarian reserve (DOR) extend well beyond reproductive concerns. Menopause. 2008;15(6):1086–1094. doi: 10.1097/gme.0b013e3181728467. - DOI - PubMed
    1. Thierring P, Beaurepaire J, Jones M, Sounders D, Tennant C. Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET) J Psychosom Res. 1993;37:481–491. doi: 10.1016/0022-3999(93)90004-Y. - DOI - PubMed
    1. Cousineu TM, Domar A. Psychological impact of infertility. Best Pract Res Clin Obstet Gynecol. 2007;21:293–308. doi: 10.1016/j.bpobgyn.2006.12.003. - DOI - PubMed
    1. Demyttenaere K, Bonte L, Gheldof M, Vervaeke M, Meuleman C, Vanderschuerem D, et al. Coping style and depression level influence outcome in in vitro fertilization. Fertil Steril. 1998;69:1026–1033. doi: 10.1016/S0015-0282(98)00089-2. - DOI - PubMed
    1. Kee BS, Jung BJ, Lee SH. A study on psychological strain in IVF patients. J Assist Reprod Genet. 2000;17:445–448. doi: 10.1023/A:1009417302758. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances