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. 2011 Jun;17(6):1074-8.
doi: 10.3201/eid/1706.101067.

Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland

Alain Kenfak-Foguena  1 , Franziska Schöni-Affolter, Phillippe Bürgisser, Andrea Witteck, Katharine E A Darling, Helen Kovari, Laurent Kaiser, John-Marc Evison, Luigia Elzi, Vanina Gurter-De La Fuente, Josef Jost, Darius Moradpour, Florence Abravanel, Jacques Izpopet, Matthais Cavassini; Data Center of the Swiss HIV Cohort Study, Lausanne, Switzerland
Affiliations

Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland

Alain Kenfak-Foguena et al. Emerg Infect Dis. 2011 Jun.

Abstract

We screened 735 HIV-infected patients in Switzerland with unexplained alanine aminotransferase elevation for hepatitis E virus (HEV) immunoglobulin G. Although HEV seroprevalence in this population is low (2.6%), HEV RNA can persist in patients with low CD4 cell counts. Findings suggest chronic HEV infection should be considered as a cause of persistent alanine aminotransferase elevation.

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Figures

Figure 1
Figure 1
Longitudinal description of blood hepatitis E virus (HEV) serology, HEV RNA, alanine aminotransferase (ALT) levels, HIV RNA, and CD4 count in patient with chronic HEV infection, positive results by real-time PCR for HEV RNA, and seroconversion to immunoglobulin (Ig) G. HAART, highly active antiretroviral therapy.
Figure 2
Figure 2
Longitudinal description of blood hepatitis E virus (HEV) serology, HEV RNA, alanine aminotransferase (ALT) levels, HIV RNA, and CD4 count in patient with positive real-time PCR results for HEV infection but without serologic seroconversion to immunoglobulin (Ig) G.
See this image and copyright information in PMC

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