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. 2011 Jun;17(6):1079-82.
doi: 10.3201/eid/1706.101558.

Macrolide resistance in Mycoplasma pneumoniae, Israel, 2010

Diana Averbuch  1 , Carlos Hidalgo-Grass, Allon E Moses, Dan Engelhard, Ran Nir-Paz
Affiliations

Macrolide resistance in Mycoplasma pneumoniae, Israel, 2010

Diana Averbuch et al. Emerg Infect Dis. 2011 Jun.

Abstract

Macrolide resistance in Mycoplasma pneumoniae is often found in Asia but is rare elsewhere. We report the emergence of macrolide-resistant M. pneumoniae in Israel and the in vivo evolution of such resistance during the treatment of a 6-year-old boy with pneumonia.

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Figures

Figure 1
Figure 1
Time elapsed and chromatogram of wild-type Mycoplasma pneumonia strain M129 (ATCC 29342) compared with results from 5 samples from a 6-year-old boy in Israel. The A2063G mutation is shown to be evolving during treatment and predominates at the end.
Figure 2
Figure 2
Real-time PCR high-resolution melting assay. A) High-resolution melt profiles are shown for wild-type (WT) Mycoplasma pneumoniae A (A2063A), macrolide resistance mutation G (A2063G) sample, and the mixed genotype sample in the normalized graph mode. B) Temperature-shifted difference graph demonstrates the deviations between WT, resistant, and mixed samples. The WT isolate has been selected to normalize the temperature shift graph and displays the deviation of samples from it.
See this image and copyright information in PMC

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