High vancomycin MIC and complicated methicillin-susceptible Staphylococcus aureus bacteremia
- PMID: 21749780
- PMCID: PMC3358192
- DOI: 10.3201/eid/1706.101037
High vancomycin MIC and complicated methicillin-susceptible Staphylococcus aureus bacteremia
Abstract
We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 ug/mL) was the only independent risk factor for development of complicated bacteremia caused by methicillin-susceptible S. aureus (odds ratio 22.9, 95% confidence interval 6.7-78.1).
Comment in
-
Reduced susceptibility to vancomycin in Staphylococcus aureus.Emerg Infect Dis. 2011 Nov;17(11):2083-4; author reply 2084. doi: 10.3201/eid1711.110799. Emerg Infect Dis. 2011. PMID: 22099110 Free PMC article. No abstract available.
References
-
- Lodise TP, Graves J, Evans A, Graffunder E, Helmecke M, Lomaestro BM, et al. Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin. Antimicrob Agents Chemother. 2008;52:3315–20. 10.1128/AAC.00113-08 - DOI - PMC - PubMed
-
- Sakoulas G, Moise-Broder PA, Schentag J, Forrest A, Moellering RC Jr, Eliopoulos GM. Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia. J Clin Microbiol. 2004;42:2398–402. 10.1128/JCM.42.6.2398-2402.2004 - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical