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. 2011 Aug;13(8):765-9.
doi: 10.1080/10286020.2011.586342.

A new staurosporine analog from Actinomycetes Streptomyces sp. (172614)

Xiao-Bin Li  1 , Jin-Shan Tang, Hao Gao, Rong Ding, Jia Li, Kui Hong, Xin-Sheng Yao
Affiliations

A new staurosporine analog from Actinomycetes Streptomyces sp. (172614)

Xiao-Bin Li et al. J Asian Nat Prod Res. 2011 Aug.

Abstract

A new staurosporine analog, 10'-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

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