Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient

Abstract

Primary angiosarcoma of the ovary (AS) is a rare entity with only 31 reported cases. The majority are pure angiosarcomas, the remainder are associated either with teratomas or conventional epithelial tumors. More than 50% of ovarian AS are disseminated at the time of diagnosis, the minority is detected in stage I. The prognosis of ovarian angiosarcoma in general is poor. Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient.

Figure 1

Cut surface of the right ovary featuring a centrally located tumor associated cyst.

Figure 2

Transformation from centrally located angiosarcoma high grade (left) to more vasculated and well differentiated tumor areas in the periphery; H&E 40×.

Figure 3

Centrally located angiosarcoma high grade with fusiform tumor component. CD31 staining 400×.

Figure 4

Atypical vascular proliferation in the cortical areas of the ovary. CD31 staining 100×.

Figure 5

Centrally located high grade angiosarcoma exhibiting atypical mitosis; H&E 200×.