First case of Segniliparus rotundus pneumonia in a patient with bronchiectasis

Abstract

We report the first case of Segniliparus rotundus pneumonia in an adult with non-cystic fibrosis bronchiectasis. All isolates were identified as S. rotundus by 16S rRNA gene sequencing and rpoB PCR-restriction analysis. Antibiotic therapy with clarithromycin and ciprofloxacin for 2 months improved the patient's condition and achieved successful sputum conversion.

Fig. 1

A 43-year-old woman with Segniliparus rotundus pneumonia. (A) A high-resolution computed tomography (HRCT) chest scan at the level of the proximal lower lobar bronchus shows extensive bronchiectasis and lobular consolidation. (B) An HRCT scan obtained at the lung base shows severe bronchiectasis in the right middle lobe. Multiple small nodules and branching centrilobular nodules form a tree-in-bud pattern in the right lower lobe.

Fig. 2

PCR restriction-enzyme polymorphism analysis (PRA). (A) Simulation of PRA of the hsp65 and rpoB genes. (B) PRA electrophoresis results. M, size marker; lanes 1 to 3, hsp65 amplicons digested by MspI from S. rugosus CIP 108378^T, S. rotundus CIP 108380^T, and the clinical isolate of this case, respectively; lines 4 to 6, rpoB amplicons digested by MspI from S. rugosus CIP 108378^T, S. rotundus CIP 108380^T, and the clinical isolate of this case, respectively; lines 7 to 9, rpoB amplicons digested by HaeIII from S. rugosus CIP 108378^T, S. rotundus CIP 108380^T, and the clinical isolate of this case, respectively.