Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Jul 26;108(30):12189-90.
doi: 10.1073/pnas.1109445108. Epub 2011 Jul 13.

Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association

Catherine A Musselman  1 , Tatiana G Kutateladze
Affiliations
Comment

Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association

Catherine A Musselman et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Methyl fingerprinting of the nucleosome. Histones are shown in blue, DNA is in green, and the Ile/Leu/Val methyl groups are in red.
Fig. 2.
Fig. 2.
A model of HMGN2 action at the nucleosome. The histone core is shown in blue, and DNA is in green. Binding of the NBD domain of HMGN2 (purple) to the acidic patch of histones (outlined by the red dotted line) and DNA near the DNA exit/entry point (outlined by the black dotted line) positions the C-terminal tail of HMGN2 to block the binding of H1. On phosphorylation (yellow circle) of the histone core, HMGN2 can be displaced from the nucleosome.
See this image and copyright information in PMC

Comment on

References

    1. Kato H, et al. Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR. Proc Natl Acad Sci USA. 2011;108:12283–12288. - PMC - PubMed
    1. Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature. 1997;389:251–260. - PubMed
    1. Makde RD, England JR, Yennawar HP, Tan S. Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature. 2010;467:562–566. - PMC - PubMed
    1. Barbera AJ, et al. The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science. 2006;311:856–861. - PubMed
    1. Andrews AJ, Luger K. Nucleosome structure(s) and stability: Variations on a theme. Annu Rev Biophys. 2011;40:99–117. - PubMed

Publication types

LinkOut - more resources