Cutaneous squamous cell carcinoma: a smoking gun but still no suspects
- PMID: 21753763
- DOI: 10.1038/jid.2011.151
Cutaneous squamous cell carcinoma: a smoking gun but still no suspects
Abstract
A viral etiology for cutaneous squamous cell carcinoma (cuSCC) has long been suspected, primarily on the basis of its dramatically increased incidence in immunocompromised individuals. In this issue, Arron and colleagues report a comprehensive hunt for viral gene transcription in cuSCC. Their findings show that it is very unlikely that any currently known virus is commonly responsible for the maintenance of this cancer.
Comment on
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Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma.J Invest Dermatol. 2011 Aug;131(8):1745-53. doi: 10.1038/jid.2011.91. Epub 2011 Apr 14. J Invest Dermatol. 2011. PMID: 21490616 Free PMC article.
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