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. 2011:7:265-73.
doi: 10.2147/TCRM.S15544. Epub 2011 Jul 1.

Conestat alfa for the treatment of angioedema attacks

Benjamin Davis  1 , Jonathan A Bernstein
Affiliations

Conestat alfa for the treatment of angioedema attacks

Benjamin Davis et al. Ther Clin Risk Manag. 2011.

Abstract

Recently, multiple C1 inhibitor (C1-INH) replacement products have been approved for the treatment of hereditary angioedema (HAE). This review summarizes HAE and its current treatment modalities and focuses on findings from bench to bedside trials of a new C1-INH replacement, conestat alfa. Conestat alfa is unique among the other C1-INH replacement products because it is produced from transgenic rabbits rather than derived from human plasma donors, which can potentially allow an unlimited source of drug without any concern of infectious transmission. The clinical trial data generated to date indicate that conestat alfa is safe and effective for the treatment of acute HAE attacks.

Keywords: HAE attacks; adverse events; androgens; patients.

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Figures

Figure 1
Figure 1
Sites of C1-inhibitor (C1-INH) regulation of the contact, complement, and fibrinolytic systems. Conestat alfa, a recombinant C1-INH, likely regulates the same sites.
See this image and copyright information in PMC

References

    1. Zuraw BL. Hereditary angiodema: a current state-of-the-art review, IV: short- and long-term treatment of hereditary angioedema: out with the old and in with the new? Ann Allergy. 2008;100(1 Suppl 2):S13–S18. - PubMed
    1. Bernstein IL. Hereditary angioedema: a current state-of-the-art review, II: historical perspective of non-histamine-induced angioedema. Ann Allergy. 2008;100(1 Suppl 2):S2–S6. - PubMed
    1. Nielsen EW, Gran JT, Straume B, et al. Hereditary angio-oedema: new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses. J Intern Med. 1996;239(2):119–130. - PubMed
    1. Davis AE., III Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema. Ann Allergy. 2008;100(1):S7–S12. - PubMed
    1. Cedzynski M, Gregorek H, Madaliński K. Possible dis-ease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults. Arch Immunol Ther Exp Warsz. 2008;56(1):69–75. - PMC - PubMed