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. 2011:5:19-23.
doi: 10.2174/1874306401105010019. Epub 2011 Jun 20.

Patients Hospitalized with pH1N1 Influenza in an Academic Community Medical Center

Hagit Bergman  1 , Lawrence L Livornese Jr, Suryaprakash Sambhara, Jerome Santoro, Scott K Dessain
Affiliations

Patients Hospitalized with pH1N1 Influenza in an Academic Community Medical Center

Hagit Bergman et al. Open Respir Med J. 2011.

Abstract

Background: The emergence of a novel strain of pandemic influenza (pH1N1) in 2009 presented significant challenges to health care facilities worldwide. In our academic community medical center in suburban Philadelphia, we noted our first pH1N1 diagnosis in September 2009. We sought to assess the impact of pH1N1 disease on our hospitalized patient population.

Methods: We prospectively collected clinical and epidemiological data on 29 consecutive patients that were admitted to our hospital with a primary or secondary diagnosis of influenza from October 1-November 30, 2009. Data were obtained through care of the patients and chart review.

Results: Prominent symptoms on admission included fever, hypoxia, cough, myalgias, and diarrhea, with leukocytosis and neutrophilia. Pre-existing medical conditions included asthma, pregnancy, immunosuppressive therapy, and sickle cell disease. All but 5 of the patients were under 60 years of age. Three patients had culture-documented bacterial or mycoplasma infections. All but two of the patients received oseltamivir. Six required admission to the intensive care unit but only one patient died.

Conclusions: Our population of hospitalized patients with novel pH1N1 influenza demonstrated many of the features that have been associated with pH1N1 disease in other populations. Most of the patients were women and none of the patients died directly as a complication of influenza. We observed a cluster of patients with a tetrad of features comprising a history of asthma, obesity, female gender, and African-American race. Individuals with this constellation of factors should be specifically targeted for pH1N1 vaccination.

Keywords: PCR; RIDT.; immunosuppression; neutrophilia; pH1N1 Influenza; vaccination.

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Figures

Fig. (1)
Fig. (1)
Positive RIDT results for adult patients (age >= 18 years of age) at the Lankenau Medical Center, August-December 2009.
Fig. (2)
Fig. (2)
Ages of the patients admitted to the Lankenau Medical Center with a diagnosis of pH1N1 influenza, October and November, 2009.
Fig. (3)
Fig. (3)
Primary admission diagnoses of the study population.
See this image and copyright information in PMC

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