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. 2011:2011:259462.
doi: 10.4061/2011/259462. Epub 2011 Jun 27.

Endoplasmic reticulum stress-related inflammation and cardiovascular diseases

Tomomi Gotoh  1 , Motoyoshi Endo, Yuichi Oike
Affiliations

Endoplasmic reticulum stress-related inflammation and cardiovascular diseases

Tomomi Gotoh et al. Int J Inflam. 2011.

Abstract

The endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane. Various types of stress from both inside and outside cells disturb ER function, thus causing unfolded or misfolded proteins to accumulate in the ER. To improve and maintain the ER functions against such stresses, the ER stress response pathway is activated. However, when the stress is prolonged or severe, apoptosis pathways are activated to remove damaged cells. It was recently reported that the ER stress pathway is also involved in the inflammatory response, whereby inflammation induces ER stress, and ER stress induces an inflammatory response. Therefore, the ER stress response pathway is involved in various diseases, including cardiovascular diseases such as atherosclerosis and ischemic diseases, in various ways. The ER stress pathway may represent a novel target for the treatment of these diseases.

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Figures

Figure 1
Figure 1
An overview of the ER stress response pathway. See the text for details.
Figure 2
Figure 2
The major signal transduction pathway in the ER stress response. See the text for details.
Figure 3
Figure 3
Involvement of ER stress response in atherosclerosis (a) and ischemia-reperfusion injury (b). See the text for details.
See this image and copyright information in PMC

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