Acute fall in glomerular filtration rate with renin-angiotensin system inhibition: a biomeasure of therapeutic success?
- PMID: 21760601
- DOI: 10.1038/ki.2011.132
Acute fall in glomerular filtration rate with renin-angiotensin system inhibition: a biomeasure of therapeutic success?
Abstract
Glomerular filtration rate (GFR) acutely declines with the introduction of renin-angiotensin system inhibition. This response is functional, not anatomical, and varies with volume status. The reduction in GFR with renin-angiotensin system inhibition may serve as a biomeasure of future therapeutic benefit.
Comment on
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An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function.Kidney Int. 2011 Aug;80(3):282-7. doi: 10.1038/ki.2011.79. Epub 2011 Mar 30. Kidney Int. 2011. PMID: 21451458 Clinical Trial.
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