Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:951629.
doi: 10.4061/2011/951629. Epub 2011 Jun 22.

B-type natriuretic Peptide in the critically ill with acute kidney injury

Massimo de Cal  1 , Mikko Haapio, Dinna N Cruz, Paolo Lentini, Andrew A House, Ilona Bobek, Grazia M Virzì, Valentina Corradi, Flavio Basso, Pasquale Piccinni, Angela D'Angelo, Jamie W Chang, Mitchell H Rosner, Claudio Ronco
Affiliations

B-type natriuretic Peptide in the critically ill with acute kidney injury

Massimo de Cal et al. Int J Nephrol. 2011.

Abstract

Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients. Aims. To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients. Methods. We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay. Results. For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL). Conclusion. Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation.

PubMed Disclaimer

Figures

Figure 2
Figure 2
Increase in median of BNP of patients with AKI on admission to ICU (P = .012).
Figure 1
Figure 1
The ROC-AUC for BNP related to the presence of AKI on admission or development of AKI during ICU stay is 0.830.
See this image and copyright information in PMC

References

    1. Bagshaw SM, Laupland KB, Doig CJ, et al. Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Critical Care. 2005;9(6):R700–R709. - PMC - PubMed
    1. Korkeila M, Ruokonen E, Takala J. Costs of care, long-term prognosis and quality of life in patients requiring renal replacement therapy durino intensive care. Journal of Intensive Care Medicine. 2000;26(12):1824–1831. - PubMed
    1. Metnitz PG, Krenn CG, Steltzer H, et al. Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Critical Care Medicine. 2002;30(9):2051–2058. - PubMed
    1. Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. Journal of the American Medical Association. 2005;294(7):813–818. - PubMed
    1. Bagshaw SM, George C, Dinu I, Bellomo R. A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrology Dialysis Transplantation. 2008;23(4):1203–1210. - PubMed

LinkOut - more resources